Intracranial Pressure Monitor Enhancement For Cerebral Hemodynamic Monitoring

Continuously monitor changes in blood flow and vascular reactivity with this non-invasive technique.

Value Proposition

Current therapies for traumatic brain injury (TBI)  primarily attempt to avoid secondary ischemic injuries, which are mediated by decreased cerebral blood flow due to elevated intracranial pressure and impaired cerebral autoregulation.  However, there is currently no reliable method for continuously monitoring cerebral blood flow used in TBI management.

This product enhances  an existing intracranial pressure (ICP) monitor, capturing high-bandwidth measurements of  heartbeat-to-heartbeat local pressure and blood  volume fluctuations. This combination of signals has been demonstrated to permit close tracking of relative constriction or dilation of peripheral arteries when applied in a non-invasive form factor, which then permits measurement of changes in blood flow given knowledge of arterial pressure and observation of certain autoregulation phenomena.

Competitive Advantage

  • Allows clinicians to determine whether regional blood flow is increasing, stable, or decreasing

  • The modified ICP monitoring catheter will be nearly identical to its existing form factor

  • Enables monitoring of blood flow in the region of the ICP monitor in addition to the monitor’s standard pressure measurement without altering the standard TBI workflow

Unique Features

  • Miniaturized piezoelectric pressure and optical blood volume sensors

  • Non-invasive heartbeat-to-heartbeat local pressure and blood volume fluctuation detection

Emerging Product Emerging Products have high confidence for commercial viability and will be ready to license in 1-2 years

Principal Investigators
Kenn Oldham PhD
Hakam Tiba, MD, MS
Craig Williamson, MD
Kevin Ward, MD

Licensing Manager
Drew Bennett

Intellectual Property
Invention Disclosure # 2018-471
Patent Application Submitted

Solution Sheet
Download Solution Sheet (PDF)

MARKET OPPORTUNITY
Useful in any trauma center where ICP measurement is critical to patient health.

Please contact the Licensing Manager, Drew Bennett, for more information.

Funding History

$223,285 in non-dilutive funding

  • 2018 $104,433 Massey Grand Challenge

  • 2022 $118,852 Massey Grand Challenge

  • Substantial departmental, school and center based support

Completed Milestones:

Funding Organizations

Publications

None at this time

Media Coverage

None at this time

Kate MurphyPICTURE, Analytic, Critical Care Life Support, Predictive Analysis, EHR, data science, general floor, machine learning